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KMID : 1146320150030020115
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Journal of Health Technology Assessment
2015 Volume.3 No. 2 p.115 ~ p.121
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Effectiveness of the Suppression of Tumorigenicity 2 for Prognosis in Heart Failure: Systematic Reviews
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Kim So-Young
Bang Hee-Young
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Abstract
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Objectives: Suppression of tumorigenicity 2 (ST2) reflects activity of the cardioprotective signal and it is a prognostic marker in heart failure. The purpose of this study is to assess the effectiveness of the ST2 for determination of the prognosis of patient with heart failure.
Methods: We searched the eight Korean databases and Ovid-MEDLINE, Ovid-EMBASE, Cochrane Library. Total 365 studies were searched and 19 studies were included in the final assessment. Each of the stages from literature search and extraction of data were carried out independently by 2 researchers. We used tools of Scottish Intercollegiate Guidelines Networks for assessment of the quality of studies.
Results: The effectiveness of the ST2 was assessed by means of association with prognosis [risk ratio (RR) or odds ratio (OR), accuracy of forecasting of the prognosis, stratification of risk], correlation with the comparators and relevance with clinical symptoms. The RR or OR of the death arising from ST2 was 1.01?4.56, the RR of hospitalization was 1.054?2.4. On the other hand, RR of hospitalization of B-type natriuretic peptide (BNP) was 1.15?2.0, the RR or OR of death arising from N-terminal pro-BNP (NT pro-BNP) was 0.19?1.241. The sensitivity/specificity of the ST2 was 64?87%/51?82% and area under the ROC curve values were 0.689?0.84. The stratification of risk (net reclassification improvement) on the death rate were reported to be significant at 9.4 and 9.9 in the 2 studies, but 1 study reported that stratification of risk of the death rate was 0.049 and stratification of risk of hospitalization rate was 0.0638. The correlation coefficients with BNP was 0.16?0.409 and with NT pro-BNP was 0.28?0.523.
Conclusion: The ST2 is effective in determining the prognosis of patients with heart failure.
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KEYWORD
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Heart failure, Prognosis, ST2, Systematic review
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